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Hexamethonium Man (Paton, 1954)
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Hexamethonium Man (Paton, 1954)


“He is a pink complexioned person, except when he has stood for a long time, when he may get pale and faint. His handshake is warm and dry. . . . He is thin because his appetite is modest; he never feels hunger pains and his stomach never rumbles. . . . As old age comes on he will suffer from retention of urine and impotence but frequency, precipitancy, and strangury will not worry him.”

Background:
  • This description by Paton, in 1954, summarises the effects of pharmacologic blockade of ganglionic transmission.
  • Hexamethonium blocks ganglionic nicotinic acetylcholine receptors.
  • Hexamethonium thus causes viagra cialis online pharmacy pharmacy of the efferent sympathetic & parasympathetic pathways.
Consequences of this disruption include:
  • Erectile dysfunction
  • Impaired bladder emptying
  • Orthostatic hypotension
  • Saliva production decreased
  • Sweating absence (anhidrosis)
  • Tear production decreased

Reference:
Paton WD. Transmission and block in autonomic ganglia. Pharmacol Rev 1954;6:59-67

Tags: Anhidrosis - Autonomic Nervous System - Erectile Dysfunction - Hexamethonium - Hypotension - Man - Orthostatic Hypotension - Parasympathetic Nervous System - Sympathetic Nervous System - Sweating
Posted by Medicalchemy
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